Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes.
Jeremiah Ong'achwa MachukiHong-Yuan ZhangJuan GengLu FuGabriel Komla AdzikaLijuan WuWenkang ShangJinxia WuLi KexueZhiwei ZhaoHong SunPublished in: Cell communication and signaling : CCS (2019)
Collectively, these results demonstrate that E2 modulates the expression of genes related to the cAMP-LTCC pathway and contributes to sex differences in cardiac contraction and responses to stress. We also show that estrogen confers cardioprotection against cardiac stress by non-genomic acute signaling via GPR30.
Keyphrases
- left ventricular
- binding protein
- heart failure
- stress induced
- hypertrophic cardiomyopathy
- poor prognosis
- acute myocardial infarction
- cardiac resynchronization therapy
- estrogen receptor
- liver failure
- mitral valve
- protein kinase
- smooth muscle
- aortic stenosis
- intensive care unit
- drug induced
- heat stress
- gene expression
- copy number
- coronary artery disease
- fatty acid
- atrial fibrillation