Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma.
Xia QianWei ZhangHua YangLanjing ZhangNingling KangJinping LaiPublished in: Exploratory research and hypothesis in medicine (2021)
Yes-associated protein-1 (YAP1) is a potent transcriptional co-activator and functions as an important downstream effector of the Hippo signaling pathway, which is key to regulating cell proliferation, apoptosis, and organ growth. YAP1 has been implicated as an oncogene for various human cancers including gastrointestinal cancers and hepatocellular carcinoma (HCC). YAP1 promotes tumorigenesis and cancer progression by multiple mechanisms, such as by promoting malignant phenotypes, expanding cancer stem cells, and inducing epithelial-mesenchymal transition. YAP1 overexpression or its activated forms are associated with advanced pathological grades and poor prognosis of cancer, and therefore targeting YAP1 may open a fertile avenue for cancer therapy. In this review, we summarize the recent evidence regarding the role of YAP1 in the carcinogenesis of gastrointestinal cancers and HCC.
Keyphrases
- poor prognosis
- epithelial mesenchymal transition
- cancer therapy
- cell proliferation
- signaling pathway
- papillary thyroid
- childhood cancer
- cancer stem cells
- long non coding rna
- endothelial cells
- pi k akt
- drug delivery
- squamous cell
- oxidative stress
- regulatory t cells
- dendritic cells
- squamous cell carcinoma
- cell death
- minimally invasive
- cell cycle
- immune response
- young adults
- cell cycle arrest
- lymph node metastasis
- transforming growth factor
- induced apoptosis
- induced pluripotent stem cells
- type iii
- pluripotent stem cells