Time-varying treatment effect modification of oral analgesic effectiveness by depressive symptoms in knee osteoarthritis: an application of structural nested mean models in a prospective cohort.

Alan M RathbunMichelle D ShardellJoseph J GalloAlice S RyanElizabeth A StuartMegan S SchulerYu DongBrock BeamerRhea MehtaJason E PeerMarc C Hochberg

Published in: International journal of epidemiology (2023)

Knee OA patients with persistent depressive symptoms and chronic pain may derive more analgesic treatment benefit than those without depressive symptoms and less pain.

Keyphrases

depressive symptoms
knee osteoarthritis
chronic pain
social support
neuropathic pain
randomized controlled trial
pain management
systematic review
total knee arthroplasty