Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort.

Kanika S Arora Thinh Ngoc Tran Yelena M Kemel Miika Mehine Ying L Liu Subhiksha Nandakumar Shaleigh A Smith A Rose Brannon Irina Ostrovnaya Konrad H Stopsack Pedram Razavi Anton Safonov Hira A Rizvi Matthew D Hellmann Joseph Vijai Thomas C Reynolds James A Fagin Jian Carrot-Zhang Kenneth Offit David B Solit Marc Ladanyi Nikolaus Schultz Ahmet Zehir Carol L Brown Zsofia K Stadler Debyani Chakravarty Chaitanya Bandlamudi Michael F Berger

Published in: Cancer discovery (2022)

We performed a comprehensive analysis of ancestral associations with somatic mutations in a real-world pan-cancer cohort, including >5,000 non-European individuals. Using an FDA-authorized tumor sequencing panel and an FDA-recognized oncology knowledge base, we detected differences in the prevalence of clinically actionable alterations, potentially contributing to health care disparities affecting underrepresented populations. This article is highlighted in the In This Issue feature, p. 2483.

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