Effect of statins on lipid metabolism-related microRNA expression in HepG2 cells.
Álvaro CerdaRaul Hernandes BortolinVictor ManriquezLuis A SalazarTomas ZambranoCristina Moreno FajardoMario Hiroyuki HirataRosario Dominguez Crespo HirataPublished in: Pharmacological reports : PR (2021)
Atorvastatin-mediated miR-129, miR-143, miR-205, miR-381, and miR-495 upregulation, and miR-29b, and miR-33a downregulation, modulate the expression of target genes involved in lipogenesis and lipid metabolism. Thus, statins may prevent hepatic lipid accumulation and ameliorate dyslipidemia.