Intestinal epithelial expression of human TNF is sufficient to induce small bowel inflammation and sacroiliitis mimicking human Spondyloarthritis.
Karlijn DebusschereDonald SouzaGerald H NaboznyEmilie DumasEveline VerheugenJulie CoudenysTeddy ManuelloFlore StappersTine DecruyMargaux MaelegheerNadia SchryversElisabeth GilisDirk ElewautPublished in: Rheumatology (Oxford, England) (2024)
Intestinal expression of hTNF is sufficient to initiate a pro-inflammatory cascade culminating in small bowel inflammation and sacroiliitis. Thus, gut-derived cytokines are sufficient to induce spondyloarthritis.