Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.

Yitian Zhou Carolina Dagli Hernandez Volker Martin Lauschke

Published in: British journal of cancer (2020)

These results provide the most comprehensive data set of DPYD and TPMT variability published to date with important implications for population-adjusted genetic profiling strategies of fluoropyrimidine and thiopurine risk factors and precision public health.

Keyphrases

public health
risk factors
electronic health record
single cell
big data
randomized controlled trial
machine learning
gene expression
copy number
artificial intelligence
neural network