Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment.

Robert SchoeppeNathalie BablSonja-Maria DeckingGabriele SchönhammerAndreas SiegmundChristina BrussKatja DettmerPeter J OefnerLinus FrickAnna WeigertJonathan JantschWolfgang HerrMichael RehliKathrin RennerMarina Kreutz

Published in: Frontiers in oncology (2023)

Our results show that GS supports myeloid cell survival in a glutamine poor environment. Notably, in addition to suppressing proliferation and survival of tumor cells, the blockade of GS also targets immune cells such as DCs and macrophages.

Keyphrases

dendritic cells
signaling pathway
endothelial cells
poor prognosis
free survival
regulatory t cells
acute myeloid leukemia
mouse model
induced pluripotent stem cells
pluripotent stem cells
binding protein