Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.
Yogesh SinghChristoph TrautweinJoan RomaniMadhuri S SalkerPeter H NeckelIsabel FraccaroliMahkameh AbeditashiNils WoernerJakob AdmardAchal DhariwalMorten Simonsen DueholmKarl-Herbert SchäferFlorian LangDaniel E OtzenHilal A LashuelOlaf RiessNicolas CasadeiPublished in: Molecular neurodegeneration (2023)
Our data emphasize that the gut microbiome dysbiosis synchronous with ageing leads to a specific alteration of gut metabolites and can be modulated by antibiotics which may affect PD pathology.