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Hilal A Lashuel

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 34

Top Venues

Nature neuroscience

NPJ Parkinson's disease

Journal of the American Chemical Society

Journal of neurochemistry

École Polytechnique Fédérale de Lausanne

Brooklyn College (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

École Polytechnique Fédérale de Lausanne May 15o 2011

Switzerland

Associate Professor :: Brain Mind Institute

Education History

Brooklyn College Jan 15o 1990 - Aug 17o 2004

United States

BSC :: Chemistry

Publications

Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Schöndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashuel
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature communications 14 (1) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Author Correction: Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience (2023)
Khalid A Ibrahim, Kristin S Grußmayer, Nathan Riguet, Lely Feletti, Hilal A Lashuel, Aleksandra Radenović
Label-free identification of protein aggregates using deep learning. Nature communications 14 (1) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Senthil T Kumar, Sergey Nazarov, Sílvia Porta, Niran Maharjan, Urszula Cendrowska, Malek Kabani, Francesco Finamore, Yan Xu, Virginia M Y Lee, Hilal A Lashuel
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nature neuroscience (2023)
Deepthy Kavungal, Pedro Magalhães, Senthil T Kumar, Rajasekhar Kolla, Hilal A Lashuel, Hatice Altug
Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases. Science advances 9 (28) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Yogesh Singh, Christoph Trautwein, Joan Romani, Madhuri S Salker, Peter H Neckel, Isabel Fraccaroli, Mahkameh Abeditashi, Nils Woerner, Jakob Admard, Achal Dhariwal, Morten Simonsen Dueholm, Karl-Herbert Schäfer, Florian Lang, Daniel E Otzen, Hilal A Lashuel, Olaf Riess, Nicolas Casadei
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease. Molecular neurodegeneration 18 (1) (2023)
Sergey Nazarov, Anass Chiki, Driss Boudeffa, Hilal A Lashuel
Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. Journal of the American Chemical Society 144 (24) (2022)
Melek Firat Altay, Alan King Lun Liu, Janice L Holton, Laura Parkkinen, Hilal A Lashuel
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta neuropathologica communications 10 (1) (2022)
Hilal A Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. NPJ Parkinson's disease 8 (1) (2022)
Pedro Magalhães, Hilal A Lashuel
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies. NPJ Parkinson's disease 8 (1) (2022)
Joan Teixidor, Salvatore Novello, Daniel Ortiz, Laure Menin, Hilal A Lashuel, Arnaud Bertsch, Philippe Renaud
On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid. Analytical chemistry 94 (29) (2022)
Senthil T Kumar, Anne-Laure Mahul-Mellier, Ramanath Narayana Hegde, Gwladys Riviere, Rani Moons, Alain Ibáñez de Opakua, Pedro Magalhães, Iman Rostami, Sonia Donzelli, Frank Sobott, Markus Zweckstetter, Hilal A Lashuel
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Science advances 8 (17) (2022)
Hilal A Lashuel
Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery. NPJ Parkinson's disease 8 (1) (2022)
Nathan Riguet, Anne-Laure Mahul-Mellier, Niran Maharjan, Johannes Burtscher, Marie Croisier, Graham William Knott, Janna Hastings, Alice Patin, Veronika Reiterer, Hesso Farhan, Sergey Nasarov, Hilal A Lashuel
Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nature communications 12 (1) (2021)
Galina Limorenko, Hilal A Lashuel
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society reviews (2021)
Rajasekhar Kolla, Pushparathinam Gopinath, Jonathan Ricci, Andreas Reif, Iman Rostami, Hilal A Lashuel
A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation. Journal of the American Chemical Society 143 (26) (2021)
Luis M A Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A Lashuel, David L Sulzer, Kostas Vekrellis, Glenda M Halliday, Julianna J Tomlinson, Michael G Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago Fleming Outeiro
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease. NPJ Parkinson's disease 7 (1) (2021)
Hilal A Lashuel
Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model: This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get". The articles are accompanied by a Preface "How good are cellular models?". Journal of neurochemistry 157 (4) (2021)
Mohamed Bilal Fares, Somanath Jagannath, Hilal A Lashuel
Reverse engineering Lewy bodies: how far have we come and how far can we go? Nature reviews. Neuroscience 22 (2) (2021)
Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P Bates, Malvindar K Singh-Bains, Michael Dragunow, Maurice A Curtis, Richard Lm Faull, Christopher A Ross, Andrea Caricasole, Hilal A Lashuel
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models. The EMBO journal 39 (17) (2020)
Johannes Burtscher, Jean-Christophe Copin, Carmen Sandi, Hilal A Lashuel
Pronounced α-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala. eNeuro 7 (4) (2020)
Anass Chiki, Jonathan Ricci, Ramanath Hegde, Luciano A Abriata, Andreas Reif, Driss Boudeffa, Hilal A Lashuel
Site-Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases. Chembiochem : a European journal of chemical biology 22 (1) (2020)
Hilal A Lashuel
What about faculty? eLife 9 (2020)
Senthil T Kumar, Sonia Donzelli, Anass Chiki, Muhammed Muazzam Kamil Syed, Hilal A Lashuel
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research. Journal of neurochemistry 153 (1) (2020)
Mahmood Haj-Yahya, Pushparathinam Gopinath, Kolla Rajasekhar, Hilda Mirbaha, Marc I Diamond, Hilal A Lashuel
Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding. Angewandte Chemie (International ed. in English) 59 (10) (2020)
Nadine Ait-Bouziad, Anass Chiki, Galina Limorenko, Shifeng Xiao, David Eliezer, Hilal A Lashuel
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau. The Journal of biological chemistry 295 (23) (2020)
Bryan Frey, Abdelrahman AlOkda, Matthew P Jackson, Nathan Riguet, James A Duce, Hilal A Lashuel
Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get. Journal of neurochemistry 157 (4) (2020)
Mahmood Haj-Yahya, Hilal A Lashuel
Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States. Journal of the American Chemical Society 140 (21) (2018)
Dordaneh Etezadi, John B Warner, Hilal A Lashuel, Hatice Altug
Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas. ACS sensors 3 (6) (2018)
John B Warner, Kiersten M Ruff, Piau Siong Tan, Edward A Lemke, Rohit V Pappu, Hilal A Lashuel
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths. Journal of the American Chemical Society 139 (41) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Hilal A Lashuel