Whole-organ decellularization of the human uterus and in vivo application of the bio-scaffolds in animal models.
Seyedeh Sima DaryabariKiarad FendereskiFariba GhorbaniMehrshad DehnaviYazdan ShafikhaniAra OmranipourSam Zeraatian-Nejad DavaniMasoumeh Majidi ZolbinSeyed Mohammad TavangarAbdol-Mohammad KajbafzadehPublished in: Journal of assisted reproduction and genetics (2022)
To the best of our knowledge, this investigation provides the first efficient perfusion-based decellularization protocol for the human uterus to obtain whole-organ scaffolds. The outcomes of this investigation could be employed in future human uterus tissue engineering studies which could ultimately result in the development of novel treatments for female infertile patients.
Keyphrases
- tissue engineering
- endothelial cells
- induced pluripotent stem cells
- end stage renal disease
- pluripotent stem cells
- healthcare
- randomized controlled trial
- chronic kidney disease
- ejection fraction
- type diabetes
- newly diagnosed
- magnetic resonance imaging
- computed tomography
- magnetic resonance
- adipose tissue
- metabolic syndrome
- skeletal muscle
- polycystic ovary syndrome
- peritoneal dialysis
- contrast enhanced