Bioconversion Products of Whey by Lactic Acid Bacteria Exert Anti-Adipogenic Effect.
Ji Soo LeeIn Kyung HyunJi-Won YoonHye-Jin SeoSeok-Seong KangPublished in: Food science of animal resources (2021)
Microbial bioconversion using lactic acid bacteria (LAB) provides several human health benefits. Although whey and whey-derived bioactive compounds can contribute to an improvement in human health, the potential anti-obesity effect of whey bioconversion by LAB has not been well studied. This study aimed to investigate whether bioconversion of whey by Pediococcus pentosaceus KI31 and Lactobacillus sakei KI36 (KI31-W and KI36-W, respectively) inhibits 3T3-L1 preadipocyte differentiation. Both KI31-W and KI36-W reduced intracellular lipid accumulation significantly, without decreasing 3T3-L1 preadipocyte proliferation. In addition, obesity-related transcription factor (peroxisome proliferator-activated receptor γ) and genes (adipocyte fatty acid-binding protein and lipoprotein lipase) were down-regulated significantly in 3T3-L1 cells in the presence of KI31-W and KI36-W. Collectively, these results suggest that bioconversion of whey by LAB exhibits anti-adipogenic activity and may be applied as a therapeutic agent for obesity.
Keyphrases
- human health
- lactic acid
- neoadjuvant chemotherapy
- risk assessment
- insulin resistance
- transcription factor
- metabolic syndrome
- type diabetes
- weight loss
- fatty acid
- binding protein
- climate change
- high fat diet induced
- microbial community
- induced apoptosis
- gene expression
- skeletal muscle
- genome wide
- cell death
- reactive oxygen species
- pi k akt