The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells.

Helena M StrickerNadine RommerswinkelSilvia KeilSandina A GnothBernd NiggemannThomas Dittmar

Published in: Cell communication and signaling : CCS (2021)

In summary, blocking PLD activity with the specific inhibitor FIPI or knocking down PDL1 expression by siRNA significantly impaired EGF-induced calcium release in MDA-MB-468-NEO and MDA-MB-468-HER2 cells, likely indicating a connection between PLD activity and PLC-γ1-mediated calcium signaling. However, how PLD activity interferes with the release of calcium from intracellular stores remains unclear. Video Abstract.

Keyphrases

breast cancer cells
cell cycle arrest
high glucose
diabetic rats
induced apoptosis
poor prognosis
growth factor
signaling pathway
cell death
reactive oxygen species
binding protein
stress induced
pluripotent stem cells