Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet.

Karin M Kirschner Anna Foryst-Ludwig Sabrina Gohlke Chen Li Roberto E Flores Ulrich Kintscher Michael Schupp Tim J Schulz Holger Scholz

Published in: Diabetologia (2021)

WT1 functions as a white adipocyte determination factor in epididymal WAT by suppressing thermogenic genes. Reducing Wt1 expression in this and other intra-abdominal fat depots may represent a novel treatment strategy in metabolic disease.

Keyphrases

high fat diet
adipose tissue
insulin resistance
high fat diet induced
fatty acid
poor prognosis
oxidative stress
genome wide
metabolic syndrome
skeletal muscle
binding protein
molecularly imprinted
solid phase extraction
type diabetes
mass spectrometry
mouse model
bioinformatics analysis
gene expression
wild type