Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet.
Karin M KirschnerAnna Foryst-LudwigSabrina GohlkeChen LiRoberto E FloresUlrich KintscherMichael SchuppTim J SchulzHolger ScholzPublished in: Diabetologia (2021)
WT1 functions as a white adipocyte determination factor in epididymal WAT by suppressing thermogenic genes. Reducing Wt1 expression in this and other intra-abdominal fat depots may represent a novel treatment strategy in metabolic disease.
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