Activation of GPER1 by G1 prevents PTSD-like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection.
Lixia ChenYang ZhangZisheng WangZhengrong ZhangJingji WangGuoqi ZhuShaojie YangPublished in: CNS neuroscience & therapeutics (2024)
G1 improved PTSD-like behaviors in SPS mice, possibly by increasing hippocampal GPER1 expression and promoting BDNF/TrkB signaling to repair synaptic and mitochondrial functional impairments. This study would provide critical mechanism for the prevention and treatment of PTSD.
Keyphrases
- posttraumatic stress disorder
- social support
- high fat diet induced
- estrogen receptor
- poor prognosis
- stress induced
- oxidative stress
- prefrontal cortex
- depressive symptoms
- reactive oxygen species
- mouse model
- combination therapy
- endoplasmic reticulum
- replacement therapy
- long non coding rna
- blood brain barrier
- cerebral ischemia