Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma.

Zhewen XiongStephen Lam ChanJingying ZhouJoaquim S L VongTsz Tung KwongXuezhen ZengHaoran WuJianquan CaoYalin TuYu FengWeiqin YangPatrick Pak-Chun WongWillis Wai-Yiu Si-TouXiaoyu LiuJing WangWenshu TangZhixian LiangJiahuan LuKa Man LiJie-Ting LowMichael Wing-Yan ChanHoward H W LeungAnthony W H ChanKa-Fai ToKevin Yuk-Lap YipYuk Ming Dennis LoJoseph Jao Yiu Sung Alfred Sze-Lok Cheng

Published in: Gut (2023)

We uncover an adaptive transcriptional programme by which tumour cells evade immune-checkpoint targeting via PPARγ/VEGF-A-mediated TME immunosuppression, thus providing a strategy for counteracting immunotherapeutic resistance in HCC.

Keyphrases

induced apoptosis
cancer therapy
insulin resistance
gene expression
endothelial cells
fatty acid
transcription factor
randomized controlled trial
vascular endothelial growth factor
type diabetes
cell death
endoplasmic reticulum stress
heat shock