RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors.

Nathaniel A K GlennDavid B FinlayEmma R CarruthersKathleen G MountjoyChristopher S Walker Natasha L Grimsey

Published in: British journal of pharmacology (2023)

Mutual influences on expression and/or function for specific accessory protein-receptor pairings raises the strong potential for physiological and disease-relevant consequences. CBR sequestration of and/or hetero-oligomerisation with accessory proteins is a possible novel mechanism for receptor crosstalk.

Keyphrases

binding protein
poor prognosis
fatty acid
long non coding rna
human health
risk assessment