Long non-coding RNAs regulate drug resistance in cancer.

Kaisheng LiuLin GaoXiaoshi MaJuan-Juan HuangJuan ChenLeli ZengCharles R AshbyChang ZouZhe-Sheng Chen

Published in: Molecular cancer (2020)

Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.

Keyphrases

long non coding rna
papillary thyroid
squamous cell
poor prognosis

systematic review
network analysis
randomized controlled trial
young adults

drug induced
combination therapy
genome wide identification

replacement therapy
genome wide analysis
meta analyses