Combinatorial immune checkpoint blockade increases myocardial expression of NLRP-3 and secretion of H-FABP, NT-Pro-BNP, interleukin-1β and interleukin-6: biochemical implications in cardio-immuno-oncology.
V QuagliarielloM PassarielloI BiscegliaA PacconeA InnoC MaureaR Rapuano LemboL MannaM IovineM L CanaleM ScherilloP A AsciertoD GabrielliC De LorenzoN MaureaPublished in: Frontiers in cardiovascular medicine (2024)
, indicate that combinatorial immune checkpoint blockade, induce a pro- inflammatory phenotype, thus indicating that these therapies should be closely monitored by the multidisciplinary team consisting of oncologists, cardiologists and immunologists.