The Palliative Care in the Metastatic Spinal Tumors. A Systematic Review on the Radiotherapy and Surgical Perspective.
Giuseppe Roberto GiammalvaGianluca FeriniFabio TorregrossaLara BrunassoSofia MussoUmberto Emanuele BenignoRosa Maria GerardiLapo BonosiRoberta CostanzoFederica PaoliniPaolo PalmiscianoGiuseppe Emmanuele Emmanuele UmanaRina Di BonaventuraCarmelo Lucio SturialeDomenico Gerardo IacopinoRosario MaugeriPublished in: Life (Basel, Switzerland) (2022)
Spine represents the most common site for metastatic disease involvement. Due to the close relationship between the spinal cord and critical structures, therapeutical management of metastatic spinal cord disease remains challenging. Spinal localization can lead to neurological sequelae, which can significantly affect the quality of life in patients with a limited life expectancy. The authors conducted a systematic literature review according to PRISMA guidelines in order to determine the impact of the most updated palliative care on spinal metastases. The initial literature search retrieved 2526 articles, manually screened based on detailed exclusion criteria. Finally, 65 studies met the inclusion criteria and were finally included in the systematic review. In the wide scenario of palliative care, nowadays, recent medical or surgical treatments represent valuable options for ameliorating pain and improving patients QoL in such this condition.
Keyphrases
- spinal cord
- palliative care
- systematic review
- neuropathic pain
- advanced cancer
- squamous cell carcinoma
- small cell lung cancer
- spinal cord injury
- end stage renal disease
- meta analyses
- newly diagnosed
- ejection fraction
- chronic pain
- early stage
- healthcare
- prognostic factors
- radiation therapy
- locally advanced
- peritoneal dialysis
- randomized controlled trial
- blood brain barrier
- pain management
- tyrosine kinase
- patient reported outcomes