Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review.
Jack GemayelAlain CheblyHampig KourieColette HannaKayane MheidlyMelissa MhannaFarah KaramDaniel GhoussainiPaula El NajjarCharbel KhalilPublished in: Advanced genetics (Hoboken, N.J.) (2024)
Cancer is one of the foremost causes of mortality. The human genome remains stable over time. However, human activities and environmental factors have the power to influence the prevalence of certain types of mutations. This goes to the excessive progress of xenobiotics and industrial development that is expanding the territory for cancers to develop. The mechanisms involved in immune responses against cancer are widely studied. Genome editing has changed the genome-based immunotherapy process in the human body and has opened a new era for cancer treatment. In this review, recent cancer immunotherapies and the use of genome engineering technology are largely focused on.
Keyphrases
- endothelial cells
- papillary thyroid
- genome editing
- crispr cas
- immune response
- squamous cell
- cancer therapy
- induced pluripotent stem cells
- pluripotent stem cells
- risk factors
- childhood cancer
- gene expression
- squamous cell carcinoma
- drug delivery
- type diabetes
- heavy metals
- lymph node metastasis
- dna methylation
- young adults
- inflammatory response