Reduced matrix metalloproteinase and collagen transcription mediated by the TGF-β/Smad pathway in passaged normal human dermal fibroblasts.
Young Il KimKyung Sook KimHye-Jin AhnIn-Hye KangMin-Kyung ShinPublished in: Journal of cosmetic dermatology (2019)
Our results suggest that reductions in the expression levels of MMPs and collagen types I and III in aging human dermal fibroblasts reflect reduced expression of TGF-β/Smad and TGF-β receptors, thus compromising the TGF-β receptor-binding capacity of fibroblasts; the NF-κB and Akt-JNK/MAPK signaling pathways may play active roles in this process.
Keyphrases
- transforming growth factor
- signaling pathway
- epithelial mesenchymal transition
- endothelial cells
- pi k akt
- poor prognosis
- wound healing
- induced apoptosis
- binding protein
- extracellular matrix
- induced pluripotent stem cells
- oxidative stress
- pluripotent stem cells
- cell proliferation
- cell death
- transcription factor
- immune response
- tissue engineering
- nuclear factor
- inflammatory response
- endoplasmic reticulum stress