Porphyra haitanensis glycoprotein regulates glucose homeostasis: targeting the liver.
Yujia OuYuehong GuoHaoyu WangZebin GuoBaodong ZhengPublished in: Food & function (2024)
In this study, we investigated the effects of glycoprotein (PG)-mediated regulation of Porphyra haitanensis on liver glucose metabolism in hyperglycemic mouse models, and sought to establish the underlying mechanism, as determined by the changes in liver gene expression and metabolic profiles. The results showed that 30-300 mg kg -1 PG upregulated the expression of the liver genes Ins1 , Ins2 , Insr , Gys2 , Gpi1 , Gck , and downregulated the expression of G6pc , G6pc2 , and G6pc3 , in a concentration-dependent manner. 300 mg kg -1 PG downregulated the concentrations of glucose-related metabolites in the liver, but upregulated lactic acid, 2-aminoacetic acid, and glucose-1-phosphate concentrations. It was assumed that PG regulated liver glucose metabolism by enriching insulin secretion, glycolysis/gluconeogenesis, and the AMPK signaling pathway, and promoting insulin secretion, glycogen synthesis, and glycolysis. Our findings supported the development of P. haitanensis and its glycoproteins as novel natural antidiabetic compounds that regulated blood glucose homeostasis.
Keyphrases
- blood glucose
- gene expression
- signaling pathway
- poor prognosis
- lactic acid
- type diabetes
- dna methylation
- skeletal muscle
- glycemic control
- mass spectrometry
- drug delivery
- oxidative stress
- epithelial mesenchymal transition
- adipose tissue
- long non coding rna
- endoplasmic reticulum stress
- single molecule
- atomic force microscopy
- high speed