Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome.

Yannick CyrValérie Lamantia Simon BissonnetteMelanie BurnetteAurèle Besse-PatinAnnie DemersMartin WabitschMichel ChrétienGaétan MayerJennifer L EstallMaya SalehMay Faraj

Published in: Physiological reports (2021)

Normocholesterolemic subjects with lower plasma PCSK9 and higher WAT surface-expression of LDLR and CD36 have higher WAT NLRP3 inflammasome activation and T2D risk factors. This may be due to LDL-induced inhibition of adipocyte function.

Keyphrases

nlrp inflammasome
adipose tissue
poor prognosis
low density lipoprotein
risk factors
insulin resistance
binding protein
long non coding rna
high glucose
diabetic rats
oxidative stress
metabolic syndrome
fatty acid
skeletal muscle