PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity.
Ju-Yi ChenYi-Pin WuChih-Yi LiHuei-Fen JhengLing-Zhen KaoChing-Chun YangSy-Ying LeuI-Chia LienWen-Tsan WengHaw-Chih TaiYu-Wei ChiouMing-Jer TangPei-Jane TsaiYau-Sheng TsaiPublished in: Journal of biomedical science (2021)
PPARγ activation attenuated obesity-induced arterial stiffening and reduced the inflammatory and oxidative status of PVAT. The improvement of the PVAT microenvironment further contributed to the amelioration of elastin fiber fragmentation, elastolytic activity, and upregulated expression of Ctss and Mmp12. Our data highlight the PVAT microenvironment as an important target against arterial stiffening in obesity and provide a novel strategy for the potential clinical use of PPARγ agonists as a therapeutic against arterial stiffness through modulation of PVAT function.
Keyphrases
- insulin resistance
- adipose tissue
- metabolic syndrome
- high fat diet induced
- weight loss
- high fat diet
- stem cells
- type diabetes
- skeletal muscle
- weight gain
- poor prognosis
- oxidative stress
- blood pressure
- left ventricular
- electronic health record
- fatty acid
- climate change
- diabetic rats
- body mass index
- machine learning
- big data
- coronary artery
- human health
- endothelial cells
- pulmonary artery
- binding protein
- deep learning
- atrial fibrillation