Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors.
Tiago FerreiraRui M Gil da CostaFrancisca DiasAdelina GamaVítor M GasparJoão F ManoPaula A OliveiraRui MedeirosPublished in: GeroScience (2024)
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dogs. CMTs are a promising comparative model for human breast cancer, due to sharing several pathophysiological features. Additionally, CMTs have a strong genetic correlation with their human counterpart, including the expression of microRNAs (miRNAs). MiRNAs are a class of non-coding RNAs that play important roles in post-translational regulation of gene expression, being implicated in carcinogenesis, tumor progression, and metastasis. Moreover, miRNAs hold promise as diagnostic, prognostic, and metastatic biomarkers. Understanding the molecular mechanisms underlying CMTs is crucial for improving diagnosis, prognosis, and monitoring of treatments. Herein, we provide a comprehensive overview of the current knowledge on miRNAs in CMTs, highlighting their roles in carcinogenesis and their potential as biomarkers. Additionally, we highlight the current limitations and critically discuss the overarching challenges in this field, emphasizing the need for future research to translate miRNA findings into veterinary clinical practice.
Keyphrases
- gene expression
- endothelial cells
- poor prognosis
- healthcare
- clinical practice
- induced pluripotent stem cells
- squamous cell carcinoma
- small cell lung cancer
- public health
- dna methylation
- pluripotent stem cells
- health information
- mental health
- risk factors
- long non coding rna
- deep learning
- big data
- human health
- single molecule