Effects of KRAS genetic interactions on outcomes in cancers of the lung, pancreas, and colorectum.

Isabella N Grabski John Victor Heymach Kenneth L Kehl Edmund S Kopetz Ken S Lau Gregory J Riely Deborah Schrag Rona Yaeger Rafael A Irizarry Kevin M Haigis

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

Our results provide greater insight into the tissue- and allele-specific associations with KRAS mutations and identify clusters of patients that are associated with survival and clinical attributes from combinations of genetic interactions with KRAS mutations.

Keyphrases

end stage renal disease
wild type
newly diagnosed
ejection fraction
genome wide
chronic kidney disease
copy number
peritoneal dialysis
type diabetes
gene expression
adipose tissue
patient reported outcomes
dna methylation
skeletal muscle