Fish oil mitigates myosteatosis and improves chemotherapy efficacy in a preclinical model of colon cancer.

Alaa A AlmasudKaitlin H GilesJohn J MiklavcicKaren J B MartinsVickie E BaracosCharles T PutmanLeluo L GuanVera C Mazurak

Published in: PloS one (2017)

Long term and adjuvant fish oil diets are equally efficacious in reducing chemotherapy-associated myosteatosis that may be occurring by reducing expression of transcription factors involved in adipogenesis/lipogenesis, and improving tumor-response to chemotherapy in a neoplastic model.

Keyphrases

locally advanced
transcription factor
poor prognosis
early stage
fatty acid
squamous cell carcinoma
type diabetes
rectal cancer
high fat diet induced
metabolic syndrome
adipose tissue
skeletal muscle
radiation induced
genome wide identification