Longitudinal profiles of plasma eicosanoids during pregnancy and size for gestational age at delivery: A nested case-control study.
Barrett M WelchAlexander P KeilThomas J van 't ErveLeesa J DeterdingJason G WilliamsFred B LihDavid E CantonwineThomas F McElrathKelly K FergusonPublished in: PLoS medicine (2020)
In this nested case-control study, we found that eicosanoids and fatty acids systematically change in maternal plasma over pregnancy. Eicosanoids from specific inflammation-related pathways were higher in mothers of SGA cases and mostly similar in mothers of LGA cases compared to controls. These findings can provide deeper insight into etiologic mechanisms of abnormal fetal growth outcomes.