Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.
Allison L FisherSydney PhillipsChia-Yu WangJoao A PauloXia XiaoGillian A MoschettaAdhvaith SridharJoseph D ManciasJodie L BabittPublished in: Blood (2024)
Iron-mediated induction of BMP6 expression by liver endothelial cells is essential for iron homeostasis regulation. We utilized multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for ZIP8 in regulating BMP6 expression under high-iron conditions.