WNT10A mutation results in severe tooth agenesis in a family of three sisters.
M F AbidM A SimpsonI A BarbosaM SeppalaM IrvingP T SharpeMartyn T CobournePublished in: Orthodontics & craniofacial research (2018)
WNT10A has previously been associated with both syndromic and non-syndromic forms of tooth agenesis, and this report further expands our knowledge of genetic variation underlying non-syndromic forms of this condition. We also demonstrate expression of WNT10A in the epithelial compartment of human tooth germs during development.