A Comprehensive Review of HER2 in Cancer Biology and Therapeutics.
Xiaoqing ChengPublished in: Genes (2024)
Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation. Aberrant HER2 signaling is implicated in various cancers, particularly in breast and gastric cancers, where HER2 overexpression or amplification correlates with aggressive tumor behavior and poor prognosis. HER2-activating mutations contribute to accelerated tumorigenesis and metastasis. This review provides an overview of HER2 biology, signaling pathways, mechanisms of dysregulation, and diagnostic approaches, as well as therapeutic strategies targeting HER2 in cancer. Understanding the intricate details of HER2 regulation is essential for developing effective targeted therapies and improving patient outcomes.
Keyphrases
- epidermal growth factor receptor
- poor prognosis
- tyrosine kinase
- advanced non small cell lung cancer
- cell proliferation
- papillary thyroid
- signaling pathway
- long non coding rna
- squamous cell
- endothelial cells
- childhood cancer
- pi k akt
- cell cycle
- small cell lung cancer
- small molecule
- lymph node metastasis
- squamous cell carcinoma
- induced pluripotent stem cells
- endoplasmic reticulum stress
- binding protein
- pluripotent stem cells