Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank.
Shishi XuShu WenYao YangJunhui HeHuazhen YangYuanyuan QuYu ZengJianwei ZhuFang FangHuan SongPublished in: Neurology (2024)
Our analyses demonstrated robust associations of body composition patterns featured by "central obesity," "muscle strength," and "arm-dominant fat distribution" with both neurodegenerative diseases and brain aging, which were partially mediated by CVDs. These findings underscore the potential of improving body composition and early CVD management in mitigating risk of neurodegenerative diseases.
Keyphrases
- body composition
- cardiovascular disease
- resistance training
- bone mineral density
- type diabetes
- insulin resistance
- metabolic syndrome
- adipose tissue
- resting state
- white matter
- cross sectional
- fatty acid
- skeletal muscle
- weight gain
- high fat diet induced
- risk assessment
- human health
- multiple sclerosis
- functional connectivity
- subarachnoid hemorrhage