Insights into pathogenesis of fatal COVID-19 pneumonia from histopathology with immunohistochemical and viral RNA studies.
Jennifer L SauterMarina K BaineKelly J ButnorDarren J BuonocoreJason C ChangAchim A JungbluthMatthias J SzabolcsSejal MorjariaSharon L MountNatasha RekhtmanElena SelbsZong-Mei ShengYongli XiaoDavid E KleinerStefania PittalugaJeffery K TaubenbergerAmy V RapkiewiczWilliam D TravisPublished in: Histopathology (2020)
Presence of SARS-CoV-2 viral RNA by NGS early in the disease course and expression of viral antigen by IHC exclusively in the acute, but not in the organising phase of DAD, suggests that the virus may play a major role in initiating the acute lung injury of DAD, but when DAD progresses to the organising phase the virus may have been cleared from the lung by the patient's immune response. These findings suggest the possibility of a major change during the disease course of COVID-19 pneumonia that may have therapeutic implications. Frequent thrombi and microthrombi may also present potential targets for therapeutic intervention.
Keyphrases
- sars cov
- ms ms
- simultaneous determination
- respiratory syndrome coronavirus
- immune response
- respiratory failure
- randomized controlled trial
- poor prognosis
- liver failure
- lps induced
- drug induced
- dendritic cells
- intensive care unit
- risk assessment
- hepatitis b virus
- binding protein
- climate change
- human health
- aortic dissection
- disease virus
- case control
- mechanical ventilation