Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Laura H PorterMitchell G LawrenceHong WangAshlee K ClarkAndrew BakshiDaisuke ObinataDavid GoodeMelissa Papargirisnull MuralDavid CloustonAndrew RyanSam NordenEva CoreyPeter S NelsonJohn T IsaacsJeremy GrummetJohn KourambasShahneen SandhuDeclan G MurphyDavid PookMark FrydenbergRenea A TaylorGail P Risbridger

Published in: The Prostate (2019)

This study has identified a protocol to reliably cryopreserve and re-establish a diverse cohort of serially transplantable PDXs of prostate cancer. This study has the potential to significantly improve the practicality of maintaining PDX models. Cryopreservation may also increase the accessibility of these important resources and provide new opportunities for preclinical studies on a broader spectrum of prostate tumors.

Keyphrases

prostate cancer
radical prostatectomy
randomized controlled trial
stem cells
climate change
cell therapy
benign prostatic hyperplasia