John T Isaacs

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 20

Top Topics

Benign Prostatic Hyperplasia

Radical Prostatectomy

Mesenchymal Stem Cells

Vascular Endothelial Growth Factor

Top Venues

Molecular cancer therapeutics

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate (2024)
Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Balk
AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics (2024)
Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Balk
AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
Mark P Labrecque, Lisha G Brown, Ilsa M Coleman, Holly M Nguyen, Susan Dalrymple, W Nathaniel Brennen, John T Isaacs, Dapei Li, Bryce Lakely, Diana C DeLucia, John K Lee, Michael T Schweizer, Daniel W Lin, Eva Corey, Peter S Nelson, Colm Morrissey
Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer. The Prostate (2023)
Mitchell G Lawrence, Renea A Taylor, Georgia B Cuffe, Lisa S Ang, Ashlee K Clark, David L Goode, Laura H Porter, Clémentine Le Magnen, Nora M Navone, Jack A Schalken, Yuzhuo Z Wang, Thomas A Kirkland, Eva Corey, John T Isaacs, Peter S Nelson, Gail P Risbridger
The future of patient-derived xenografts in prostate cancer research. Nature reviews. Urology (2023)
John T Isaacs, Susan L Dalrymple, Lizamma Antony, David Marc Rosen, Ilsa M Coleman, Peter S Nelson, Maya Kostova, Iain A Murray, Gary H Perdew, Samuel R Denmeade, Emmanuel S Akinboye, W Nathaniel Brennen
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer. The Prostate (2023)
Jesse C Patterson, Andreas Varkaris, Peter J P Croucher, Maya Ridinger, Susan L Dalrymple, Mannan Nouri, Fang Xie, Shohreh Varmeh, Oliver Jonas, Matthew A Whitman, Sen Chen, Saleh Rashed, Lovemore Makusha, Jun Luo, John T Isaacs, Mark G Erlander, David J Einstein, Steven P Balk, Micheal B Yaffe
Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling. Cancer research (2022)
Laura A Sena, W Nathaniel Brennen, John T Isaacs
There are gremlins in prostate cancer. Nature cancer 3 (5) (2022)
Rajendra Kumar, Janet Mendonca, Olutosin Owoyemi, Kavya Boyapati, Naiju Thomas, Suthicha Kanacharoen, Max Coffey, Deven Topiwala, Carolina Gomes, Busra Ozbek, Tracy Jones, Marc Rosen, Liang Dong, Sadie Wiens, W Nathaniel Brennen, John T Isaacs, Angelo M DeMarzo, Mark C Markowski, Emmanuel S Antonarakis, David Z Qian, Kenneth J Pienta, Drew M Pardoll, Michael A Carducci, Samuel R Denmeade, Sushant K Kachhap
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Cancer research 81 (23) (2021)
Oliver C Rogers, Lizamma Antony, Oren Levy, Nitin Joshi, Brian W Simons, Susan L Dalrymple, D Marc Rosen, Andrew J Pickering, Haoyue Lan, Heidi Kuang, Sudhir H Ranganath, Lei Zheng, Jeffrey M Karp, S Peter Howard, Samuel R Denmeade, John T Isaacs, W Nathaniel Brennen
Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer. Molecular cancer therapeutics 19 (11) (2020)
Yezi Zhu, Susan L Dalrymple, Ilsa Coleman, S Lilly Zheng, Jianfeng Xu, Jody E Hooper, Emmanuel S Antonarakis, Angelo M De Marzo, Alan K Meeker, Peter S Nelson, William B Isaacs, Samuel R Denmeade, Jun Luo, W Nathaniel Brennen, John T Isaacs
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors. Oncogene 39 (45) (2020)
W Nathaniel Brennen, Daniel L J Thorek, Wen Jiang, Timothy E G Krueger, Lizamma Antony, Samuel R Denmeade, John T Isaacs
Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy. Immunotherapy 13 (2) (2020)
Laura H Porter, Mitchell G Lawrence, Hong Wang, Ashlee K Clark, Andrew Bakshi, Daisuke Obinata, David Goode, Melissa Papargiris, null Mural, David Clouston, Andrew Ryan, Sam Norden, Eva Corey, Peter S Nelson, John T Isaacs, Jeremy Grummet, John Kourambas, Shahneen Sandhu, Declan G Murphy, David Pook, Mark Frydenberg, Renea A Taylor, Gail P Risbridger
Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer. The Prostate 79 (11) (2019)
Nora M Navone, Wytske M van Weerden, Robert L Vessella, Elizabeth D Williams, Yuzhuo Wang, John T Isaacs, Holly M Nguyen, Zoran Culig, Gabri van der Pluijm, Cyril A Rentsch, Rute B Marques, Corrina M A de Ridder, Lukas Bubendorf, George N Thalmann, William Nathaniel Brennen, Frederic Romain Santer, Patrizia L Moser, Peter Shepherd, Eleni Efstathiou, Hui Xue, Dong Lin, Jeroen Buijs, Tjalling Bosse, Anne Collins, Norman Maitland, Mark Buzza, Michelle Kouspou, Ariel Achtman, Renea A Taylor, Gail Risbridger, Eva Corey
Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models. The Prostate 78 (16) (2018)
Emmanuel S Akinboye, Oliver C Rogers, John T Isaacs
2-fluoro-5-maleimidobenzoic acid-linked albumin drug (MAD) delivery for selective systemic targeting of metastatic prostate cancer. The Prostate 78 (9) (2018)
Timothy E Krueger, Daniel L J Thorek, Alan K Meeker, John T Isaacs, W Nathaniel Brennen
Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer? The Prostate 79 (3) (2018)