Evaluation of Fecal Inflammatory Biomarkers to Identify Bacterial Diarrhea Episodes: Systematic Review and Protocol for the Enterics for Global Health Shigella Surveillance Study.
Courtney BabbHenry BadjiMd Taufiqur Rahman BhuiyanJennifer CornickSonia QureshiCatherine SonyeWagner V Shapiama LopezMehreen AdnanHannah E AtlasKehkashan BegumStephanie A BrennhoferBubacarr E CeesayAbdoulie K CeesayNigel A CunliffePaul F Garcia BardalesShahinur HaqueBri'Anna HorneM Jahangir HossainJunaid IqbalMd Taufiqul IslamSadia IslamFarhana KhanamKaren L KotloffThandizo MalemiaKatia Manzanares VillanuevaGertrude Malola MillionVitumbiko MunthaliJohn Benjamin OchiengBilly OgwelMaribel Paredes OlorteguiRichard OmorePatricia B PavlinacJames A Platts-MillsKhandra T SearsOusman SeckaSharon M TennantPablo Peñataro YoriMohammad Tahir YousafzaiKhuzwayo C JereMargaret N KosekStephen MungaUsman N IkumapayiFirdausi QadriFarah Naz QamarElizabeth T Rogawski McQuadePublished in: Open forum infectious diseases (2024)
Our evaluation of inflammatory biomarkers to distinguish diarrhea etiologies as determined by qPCR will provide an important addition to the prior literature, which was likely biased by the limited sensitivity of the gold standard diagnostics used. We will determine whether point-of-care biomarker tests could be a viable strategy to inform treatment decision making and increase appropriate targeting of antibiotic treatment to bacterial diarrhea episodes.