Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells.
Chiemi SakaiMari IshidaHideo OhbaHiromitsu YamashitaHitomi UchidaMasao YoshizumiTakafumi IshidaPublished in: PloS one (2017)
Our results suggested that EPA and DHA attenuate oxidative stress-induced DNA damage in vascular endothelial cells through upregulation of NRF2-mediated antioxidant response. Therefore omega-3 fatty acids likely help prevent cardiovascular disease, at least in part, by their genome protective properties.
Keyphrases
- dna damage
- endothelial cells
- oxidative stress
- fatty acid
- cardiovascular disease
- dna repair
- high glucose
- type diabetes
- cell proliferation
- poor prognosis
- vascular endothelial growth factor
- signaling pathway
- genome wide
- anti inflammatory
- coronary artery disease
- dna methylation
- metabolic syndrome
- cardiovascular risk factors