Evaluation of Hepatoprotective Effects of Piperlongumine Derivative PL 1-3-Loaded Albumin Nanoparticles on Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Mice.
Pengxiao LiXiaoyuan GuoTing LiuQing LiuJie YangGuoyun LiuPublished in: Molecular pharmaceutics (2022)
In recent years, piperlongumine (PL) having specific cytotoxicity has attracted considerable attention for anticancer activity. Through structural modification, the active derivative PL 1-3 shows potential anti-inflammatory activity and low cytotoxicity, but its water solubility is low. Here, PL 1-3-loaded bovine serum albumin nanoparticles (1-3 NPs) were prepared and characterized, which can improve the dissolution. 1-3 NPs exhibited effective hepatoprotective effects on lipopolysaccharide/d-galactosamine-induced acute liver injury of mice, which was similar to liver injury in clinical settings. 1-3 NPs treatment can inhibit inflammation, oxidative stress, and apoptosis via the downregulation of NF-κB signaling pathways, the activation of Nrf2/HO-1 signaling pathways, and the inhibition of expression of Bax and caspase 3 proteins. The above results demonstrated that PL 1-3-loaded bovine serum albumin nanoparticles possessed potential value in intervention of inflammation-based liver injury.
Keyphrases
- liver injury
- oxidative stress
- drug induced
- induced apoptosis
- signaling pathway
- drug delivery
- pi k akt
- ischemia reperfusion injury
- lps induced
- diabetic rats
- dna damage
- cancer therapy
- inflammatory response
- toll like receptor
- randomized controlled trial
- high fat diet induced
- poor prognosis
- wound healing
- cell cycle arrest
- endoplasmic reticulum stress
- risk assessment
- replacement therapy
- climate change
- binding protein
- metabolic syndrome
- type diabetes
- wild type
- insulin resistance
- skeletal muscle
- adipose tissue