IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.
Andrew J HouRyan M ShihBenjamin R UyAmanda ShaferZe Nan L ChangBegonya Comin-AnduixMiriam GuemesZoran GalicSu PhyuHideho OkadaKatie B GrausamJoshua J BreunigChristine E BrownDavid A NathansonRobert M PrinsYvonne Y ChenPublished in: Neuro-oncology (2024)
Our findings demonstrate that by reprogramming tumor-specific T-cell responses to TGF-β, bispecific IL-13Rα2/TGF-β CAR-T cells resist and remodel the immunosuppressive TME to drive potent anti-tumor responses in GBM.