Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.
Tigist Y TamirShreya ChaudharyAnnie X LiSonia E TrojanCameron T FlowerPaula VoYufei CuiJeffrey C DavisRachit S MukkamalaFrancesca N VendittiAlissandra L HillisAlex TokerMatthew G Vander HeidenJessica Brooke SpinelliNorman J KennedyRoger J DavisForest M WhitePublished in: bioRxiv : the preprint server for biology (2024)
By employing a multi-disciplinary approach we stratify structural features of phosphorylation sites on metabolic enzymes, map the systems level changes induced by obesity, identify key pathways with sex specific phosphoproteomic responses, and validate the functional role of phosphorylation sites for select enzymes.