Alex Toker

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 12

Top Topics

Breast Cancer Cells

Transcranial Magnetic Stimulation

Tyrosine Kinase

High Throughput

Top Venues

Science signaling

Cancer research

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Alissandra L Hillis, Timothy D Martin, Haley E Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S Persky, David E Root, Myles A Brown, Karen Cichowski, Stephen J Elledge, Taru Muranen, David A Fruman, Simon T Barry, John Gerard Clohessy, Ralitsa R Madsen, Alex Toker
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer. Cancer research (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Tigist Y Tamir, Shreya Chaudhary, Annie X Li, Sonia E Trojan, Cameron T Flower, Paula Vo, Yufei Cui, Jeffrey C Davis, Rachit S Mukkamala, Francesca N Venditti, Alissandra L Hillis, Alex Toker, Matthew G Vander Heiden, Jessica Brooke Spinelli, Norman J Kennedy, Roger J Davis, Forest M White
Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. bioRxiv : the preprint server for biology (2024)
Christian C Dibble, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, Thomas T Zengeya, Emily B Cohen, Min Yuan, Benjamin D Hopkins, Jordan L Meier, John Gerard Clohessy, John M Asara, Lewis C Cantley, Alex Toker
PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature 608 (7921) (2022)
Laura E Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Zheqi Li, Anne Trinh, Marco Seehawer, Bojana Jovanovic, Maša Alečković, Callahan M Wilde, Renee C Geck, Shaokun Shu, Natalie L Kingston, Nicholas W Harper, Vanessa Almendro, Alanna L Pyke, Shawn B Egri, Malvina Papanastasiou, M Kendell Clement, Ningxuan Zhou, Sarah R Walker, Jacqueline Salas, So Yeon Park, David A Frank, Alexander Meissner, Jacob D Jaffe, Piotr Sicinski, Alex Toker, Franziska Michor, Henry W Long, Beth A Overmoyer, Kornelia Polyak
JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states. Cancer research (2022)
Ralitsa R Madsen, Emily C Erickson, Oscar M Rueda, Xavier Robin, Carlos Caldas, Alex Toker, Robert K Semple, Bart Vanhaesebroeck
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. PLoS genetics 17 (11) (2021)
Renee C Geck, Jackson R Foley, Tracy Murray Stewart, John M Asara, Robert A Casero, Alex Toker
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy. The Journal of biological chemistry 295 (19) (2020)
Emilie Clement, Hiroyuki Inuzuka, Naoe Taira Nihira, Wenyi Wei, Alex Toker
Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Science signaling 11 (521) (2018)
Evan C Lien, Laura Ghisolfi, Renee C Geck, John M Asara, Alex Toker
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science signaling 10 (510) (2017)