Phlebotomy resulting in controlled hypovolaemia to prevent blood loss in major hepatic resections (PRICE-1): a pilot randomized clinical trial for feasibility.
Guillaume MartelLaura BakerC WherrettD A FergussonE SaidenbergA WorknehS SaeedK GadboisR JeeJ McVicarP RaoC ThompsonP WongJ Abou KhalilK A BertensF K BalaaPublished in: The British journal of surgery (2020)
Endpoints were met successfully, but no difference in EBL was found in this feasibility study. A multicentre trial (PRICE-2) powered to identify a difference in perioperative blood transfusion is justified. Registration number: NCT02548910 ( http://www.clinicaltrials.gov).