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Meta-Analysis on Induction Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma.

Maïmouna ManéSofian BenkhaledTatiana DraganMarianne PaesmansSylvie BeauvoisYassine LalamiPetr SzturzP Macoumba GayeJan B VermorkenDirk Van Gestel
Published in: The oncologist (2020)
Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively common disease in some parts of the world, with a rather poor prognosis due to its high metastatic potential. The role of induction chemotherapy (ICT) has always been controversial. This meta-analysis found that ICT followed by concurrent chemoradiotherapy (CCRT) in LA-NPC is associated with a significant clinical improvement in both overall survival and progression-free survival compared with CCRT alone. ICT should be considered as a standard option in patients with LA-NPC.
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