Meta-Analysis on Induction Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma.
Maïmouna ManéSofian BenkhaledTatiana DraganMarianne PaesmansSylvie BeauvoisYassine LalamiPetr SzturzP Macoumba GayeJan B VermorkenDirk Van GestelPublished in: The oncologist (2020)
Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively common disease in some parts of the world, with a rather poor prognosis due to its high metastatic potential. The role of induction chemotherapy (ICT) has always been controversial. This meta-analysis found that ICT followed by concurrent chemoradiotherapy (CCRT) in LA-NPC is associated with a significant clinical improvement in both overall survival and progression-free survival compared with CCRT alone. ICT should be considered as a standard option in patients with LA-NPC.
Keyphrases
- locally advanced
- poor prognosis
- free survival
- rectal cancer
- squamous cell carcinoma
- systematic review
- neoadjuvant chemotherapy
- radiation therapy
- phase ii study
- long non coding rna
- meta analyses
- small cell lung cancer
- case control
- randomized controlled trial
- clinical trial
- risk assessment
- climate change
- study protocol