Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota.
Cécilia LandmanJean-Pierre GrillJean-Maurice MalletPhilippe MarteauLydie HumbertEric Le Balc'hMarie-Anne MaubertKevin PerezWahiba ChaaraLoic BrotLaurent BeaugerieHarry SokolSophie ThenetDominique RainteauPhilippe SeksikElodie Quévrainnull nullPublished in: PloS one (2018)
We identified AHLs in the human gut microbiota and discovered a new and prominent AHL, 3-oxo-C12:2, which correlates with normobiosis and exerts a protective effect on gut epithelial cells.