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FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.

Jessica W TsaiPaloma CejasDayle K WangSmruti K PatelDavid W WuPhonepasong ArounleutXin WeiNingxuan ZhouSudeepa SyamalaFrank P B DubiosAlexander CraneKristine PeltonJayne VogelzangCecilia SousaAudrey BaguetteXiaolong ChenAlexandra-Larisa ConduratSarah E Dixon-ClarkeKevin Ning ZhouSophie D LuElizabeth M GonzalezMadison S ChaconJeromy J DigiacomoRushil KumbhaniDana R NovikovJ'Ya HunterMaria TsoliDavid S ZieglerUta DirksenNatalie JagerGnana Prakash BalasubramanianChristof Maria KrammMichaela NathrathStefan S BielackSuzanne J BakerJinghui ZhangJames M McFarlandGad A GetzFrançois AguetNada JabadoOlaf WittStefan M PfisterKeith L LigonVolker HovestadtClaudia L KleinmanHenry W LongDavid T W JonesPratiti BandopadhayayTimothy N Phoenix
Published in: Cancer research (2022)
This work identifies a novel promoter that drives aberrant FOXR2 expression and delineates FOXR2 as a pan-cancer oncogene that specifically activates ETS transcriptional circuits across human cancers. See related commentary by Liu and Northcott, p. 2977.
Keyphrases
  • transcription factor
  • papillary thyroid
  • gene expression
  • squamous cell
  • endothelial cells
  • dna methylation
  • poor prognosis
  • lymph node metastasis
  • childhood cancer
  • squamous cell carcinoma
  • genome wide
  • long noncoding rna