FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.
Jessica W TsaiPaloma CejasDayle K WangSmruti K PatelDavid W WuPhonepasong ArounleutXin WeiNingxuan ZhouSudeepa SyamalaFrank P B DubiosAlexander CraneKristine PeltonJayne VogelzangCecilia SousaAudrey BaguetteXiaolong ChenAlexandra-Larisa ConduratSarah E Dixon-ClarkeKevin Ning ZhouSophie D LuElizabeth M GonzalezMadison S ChaconJeromy J DigiacomoRushil KumbhaniDana R NovikovJ'Ya HunterMaria TsoliDavid S ZieglerUta DirksenNatalie JagerGnana Prakash BalasubramanianChristof Maria KrammMichaela NathrathStefan S BielackSuzanne J BakerJinghui ZhangJames M McFarlandGad A GetzFrançois AguetNada JabadoOlaf WittStefan M PfisterKeith L LigonVolker HovestadtClaudia L KleinmanHenry W LongDavid T W JonesPratiti BandopadhayayTimothy N PhoenixPublished in: Cancer research (2022)
This work identifies a novel promoter that drives aberrant FOXR2 expression and delineates FOXR2 as a pan-cancer oncogene that specifically activates ETS transcriptional circuits across human cancers. See related commentary by Liu and Northcott, p. 2977.