Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort.
Kamyar MoradiBahram MohajerAli GuermaziC Kent KwohClifton O BinghamSoheil MohammadiXu CaoMei WanFrank W RoemerShadpour DemehriPublished in: Journal of cachexia, sarcopenia and muscle (2024)
Preclinical rheumatoid arthritis is associated with a decrease in muscle cross-sectional area and an increase in intermuscular adipose tissue, similar to rheumatoid cachexia in clinical rheumatoid arthritis. These findings suggest the presence of cachexia in the preclinical phase of rheumatoid arthritis. Given that cachexia, which can exacerbate health outcomes, is potentially modifiable, this study emphasizes the importance of early identification of patients in their preclinical phase.
Keyphrases
- rheumatoid arthritis
- disease activity
- cross sectional
- magnetic resonance imaging
- adipose tissue
- cell therapy
- end stage renal disease
- ankylosing spondylitis
- interstitial lung disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- type diabetes
- computed tomography
- systemic lupus erythematosus
- insulin resistance
- rheumatoid arthritis patients
- skeletal muscle
- quality improvement
- magnetic resonance
- peritoneal dialysis
- stem cells
- bone marrow
- mesenchymal stem cells
- knee osteoarthritis