Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study.
Susanna SlaterAnnette BryantMaria AresuRuwaida BegumHsiang-Chi ChenClare PeckittRetchel Lazaro-AlcausiPaul CarterGayathri AnandappaShelize KhakooLucinda MelcherVanessa PotterFrancisca M MartiJoseph HuangGraham BranaganNicol GeorgeMuti AbulafiSarah DuffAshraf RajaAshish GuptaNicholas WestLeslie A BucheitThereasa A RichIan ChauDavid CunninghamNaureen Starlingnull nullPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Tissue-free MRD detection with longitudinal sampling predicts recurrence in patients with stage I to III CRC without the need for tissue sequencing. The UK TRACC Part C study is currently investigating the potential for ACT de-escalation in patients with undetectable postoperative ctDNA, given the high NPV indicating a low likelihood of residual disease.