Combined loss of TFF3 and PTEN is associated with lethal outcome and overall survival in men with prostate cancer.
Hatem Abou-OufSunita GhoshAdrian BoxNallasivam PalanisamyTarek A BismarPublished in: Journal of cancer research and clinical oncology (2019)
The study documents for the first time significant association for combined status of TFF3 expression and PTEN loss in OS and PCSM in patients not managed by surgical intervention. Prospective assessment of PTEN and TFF3 may provide further insight into molecularly subtyping PCa and aid in stratifying patients at risk for lethal disease.
Keyphrases
- prostate cancer
- end stage renal disease
- ejection fraction
- newly diagnosed
- cell proliferation
- chronic kidney disease
- randomized controlled trial
- prognostic factors
- peritoneal dialysis
- poor prognosis
- pi k akt
- long non coding rna
- radical prostatectomy
- patient reported outcomes
- signaling pathway
- middle aged
- clinical evaluation