Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy.
Bruno ScherrerJulien GuiraudGiovanni AddoloratoHenri-Jean AubinAndrea de BejczyAmine BenyaminaWim van den BrinkFabio CaputoMaurice DematteisAnna E GoudriaanAntoni GualFalk KieferLorenzo LeggioOtto-Michael LeschIcro MaremmaniDavid J NuttFrançois PaillePascal PerneyRoch PoulnaisQuentin RaffaillacJürgen RehmBenjamin RollandNicolas SimonBo SöderpalmWolfgang H SommerHenriette WalterRainer SpanagelPublished in: Alcoholism, clinical and experimental research (2021)
Pharmacological RCTs for AD should select high-severity patients to decrease the magnitude and variability in the placebo effect and and improve the efficiency of drug development efforts for AD.